We Are Fumbling the Fight Against AIDS

July 23, 2025

Senate Republicans saved some PEPFAR funding at the last moment—but Trump has already heavily damaged the program.

THOUSANDS OF SCIENTISTS, PUBLIC HEALTH OFFICIALS, and advocates for HIV treatment gathered in Kigali, Rwanda last week for what could have been—and should have been—a moment of celebration.

The occasion was the biennial meeting of the International AIDS Society. And the would-be cause for celebration was the World Health Organization’s announcement that it was officially endorsing use of a new, twice-a-year injectable form of PrEP, a medication that protects people from contracting HIV even if they are exposed. PrEP, which is the acronym for pre-exposure prophylaxis, is more than 99 percent effective, making it the best medical weapon for stopping the virus’s spread.

That’s no small matter, given that last year an estimated 1.3 million people around the world contracted HIV and an estimated 600,000 died from conditions related to AIDS. PrEP has helped bring those numbers down from where they were a few years ago, but distributing it has been an ongoing struggle, for a variety of reasons including everything from logistical difficulties in the parts of Africa where the epidemic is most severe to social pressures not to take the pills.

The injectable form of PrEP holds out the promise of overcoming those and other barriers, which is why researchers and advocates have been calling it a “game changer” that could “break the back of the epidemic.”

But injectable PrEP comes with its own challenges. Somebody has to buy and distribute the shots, and then somebody has to administer them through clinics and other facilities. Until a few months ago, the global health community had been counting on its usual partner, the United States, to help with these tasks. But now that partner is taking several giant steps back, thanks to Donald Trump.

Since taking office, the Trump administration has dramatically downsized global health assistance by cutting off funds for critical programs and shutting down the U.S. Agency for International Development (USAID), which had managed many of them. The effects were a big topic of discussion in Kigali, where researchers presented new data from several African nations showing that visits to clinics, HIV testing, and the initiation of treatment had all declined significantly.

The numbers were the first concrete evidence of something modelers have been predicting for months: namely, that Trump administration cuts would mean less prevention and care, which will ultimately mean more death. It was also consistent with anecdotal reports that health officials shared in Kigali about clinics closing and programs shuttering: Officials were heartened by all the workers showing up to volunteer, even though they weren’t getting paid, but despairing that someday the volunteers won’t be able to afford to show up anymore.

“I wouldn’t say it was panic, but there were alarm bells going off—it was real and palpable,” Mitchell Warren, executive director of the advocacy group AVAC, told me in a phone interview.

The stories and the anecdotes from Kigali—along with prior journalistic accounts from the likes of New York Times columnist Nick Kristof and former USAID Deputy Director Atul Gawande—are a powerful, sobering corrective to the frothy promises of Trump officials like Secretary of State Marco Rubio, who insisted in recent congressional testimony that “no one had died” because of cuts to global health aid.

They also put into proper perspective another development on the global health front from last week—a bill signed into law by President Trump that offered a faint measure of hope but also reinforced just how bad things have gotten.

THAT NEWS WAS CONGRESS APPROVING a so-called budget rescission, better understood as a measure pulling back and canceling money it had previously appropriated. The Trump administration had requested the rescission, largely to codify cuts it was already making on its own by simply refusing to spend money.

A bunch of that money had been allocated to foreign aid, which was one of the first big tranches of spending that the Trump administration blocked after taking office in January. But in approving the rescission, the Republicans in the Senate pushed back on one particular element: They insisted on restoring about $400 million in funding cuts the president had proposed for PEPFAR, the anti-HIV program President George W. Bush launched in 2003 that has saved literally tens of millions of lives.

It was a rare show of mettle by congressional Republicans, who have passed up so many other opportunities to confront the Trump administration. Perhaps it was legislative muscle memory, from a time when PEPFAR enjoyed strong, bipartisan support. Or perhaps it was pressure from Christian organizations, which were among the earliest champions of PEPFAR and have fought for it ever since.

The news buoyed spirits in Kigali, attendees told me, because it was a sign that the United States still had some commitment to the cause of fighting HIV—and maybe to global health more generally, since Senate Republicans also included language to “protect” programs related to malaria, tuberculosis, and malnutrition.

But with the dash of optimism came a dollop of resignation—because the package still cuts some global health money, and because restoring the PEPFAR appropriation is not the same thing as making sure the administration will spend it.

Organizations working with PEPFAR have been learning this the hard way ever since late January, when the Trump administration first blocked all foreign assistance. The administration then issued waivers for certain vital, lifesaving programs, PEPFAR among them. But even with the waivers in place, organizations working with PEPFAR struggled to get their money.

One reason was that the administration didn’t make clear what qualified as lifesaving, leaving organizations unsure of what they could and couldn’t still do. Another was that the administration was in the process of dismantling USAID, which had primary responsibility for managing PEPFAR.

The State Department ended up absorbing those responsibilities, as part of what Rubio billed as a reorganization to improve efficiency. But the transition was abrupt and hardly seamless, with a depleted staff at State struggling to handle its new portfolio.

“A lot of the staff that are responsible for the day-to-day management and correspondence with the NGOs [nongovernmental organizations] were the staff that all got fired,” Will Lewis, a policy specialist at the Christian humanitarian organization World Relief told me. “A lot of the NGOs have lost their main point of contact, and people are still trying to figure out who they should be talking to.”

Even technology became an issue, according to Elisha Dunn-Georgiou, president of the Global Health Council, because the State Department payment system didn’t work the same way USAID’s had.

“The waivers were a great kind of political statement,” Dunn-Georgiou told me, “but had nothing to do with getting paid.”

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