This session will highlight priority public health research needed to help build an evidence base to guide implementation of capacity building efforts aimed at enhancing global health security. Featuring presenters from CDC as well as from Harvard University and Georgetown University, this session will share country examples as well as global efforts to measure and advance progress. This session will be of great interest to academic-based global health programs as well as to organizations working on global health at the country level. The Centers for Disease Control and Prevention (CDC) is working with many partners including WHO, ministries of health, and universities to develop public health systems and workforce, improve technical capacity and partnerships, and conduct applied research aimed at protecting the health of Americans and people around the world. Through resources and partnerships available from several sources, particularly the Global Health Security Agenda (GHSA), measurable improvements in the public health systems have been achieved in many countries, helping them to achieve compliance with WHO’s International Health Regulations. Despite encouraging progress, many countries are still unable to rapidly detect and control a public health threat and therefore remain noncompliant with the WHO IHR. To address these gaps and thereby accelerate efforts to strengthen global health security, further public health research is needed, a particular priority public health research need is in determining the most effective implementation approaches for responding to global public health threats and building global health security capacity.